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Headcanon:
House was a heavy smoker when he and Wilson met.
Like a pack day, chain smokes on his lunch break, type smoker.
Wilson, being an oncologist, hates it. Once they’ve developed a close enough friendship Wilson nags constantly about how terrible cigarettes are for you, and how if House had to see as many cases of lung cancer in a day as he does he would quit cold turkey.
House comes back of course with sarcastic comments and deflection and sometimes immediately lights up another smoke just to annoy Wilson.
But after a couple years they are out together and Wilson notices House hasn’t been smoking, but has been chewing a lot of gum. He realizes House didn’t come annoy him to go outside with him at lunch either.
The next time House pulls out the gum, Wilson asks for a piece. House says no and they scuffle until Wilson manages to get the package from House’s hand and lo and behold - it’s nicotine gum.
Wilson is floored. House is actually quitting smoking. For some reason this seems to embarrass House, so Wilson keeps it to himself how proud he is of him.
It backfires slightly though, because now instead of pestering Wilson to go outside and sit with him while he smokes, House is pestering Wilson into buying him lunch, because “If you won’t let me smoke, you can at least buy me lunch.”