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What Science is Launching to Space?

The tenth SpaceX cargo resupply mission launched to the International Space Station on Feb. 18, and is carrying science ranging from protein crystal growth studies to Earth science payloads. Here’s a rundown of some of the highlights heading to the orbiting laboratory.

The CASIS PCG 5 investigation will crystallize a human monoclonal antibody, developed by Merck Research Labs, that is currently undergoing clinical trials for the treatment of immunological disease. Results from this investigation have the potential to improve the way monoclonal antibody treatments are administered on Earth.

Without proteins, the human body would be unable to repair, regulate or protect itself. Crystallizing proteins provides better views of their structure, which helps scientists to better understand how they function. Often times, proteins crystallized in microgravity are of higher quality than those crystallized on Earth. LMM Biophysics 1 explores that phenomena by examining the movement of single protein molecules in microgravity. Once scientists understand how these proteins function, they can be used to design new drugs that interact with the protein in specific ways and fight disease.

Much like LMM Biophysics 1, LMM Biophysics 3 aims to use crystallography to examine molecules that are too small to be seen under a microscope, in order to best predict what types of drugs will interact best with certain kinds of proteins. LMM Biophysics 3 will look specifically into which types of crystals thrive and benefit from growth in microgravity, where Earth’s gravity won’t interfere with their formation. Currently, the success rate is poor for crystals grown even in the best of laboratories. High quality, space-grown crystals could improve research for a wide range of diseases, as well as microgravity-related problems such as radiation damage, bone loss and muscle atrophy.

Nanobiosym Predictive Pathogen Mutation Study (Nanobiosym Genes) will analyze two strains of bacterial mutations aboard the station, providing data that may be helpful in refining models of drug resistance and support the development of better medicines to counteract the resistant strains.

During the Microgravity Expanded Stem Cells investigation, crew members will observe cell growth and morphological characteristics in microgravity and analyze gene expression profiles of cells grown on the station. This information will provide insight into how human cancers start and spread, which aids in the development of prevention and treatment plans. Results from this investigation could lead to the treatment of disease and injury in space, as well as provide a way to improve stem cell production for human therapy on Earth.

The Lightning Imaging Sensor will measure the amount, rate and energy of lightning as it strikes around the world. Understanding the processes that cause lightning and the connections between lightning and subsequent severe weather events is a key to improving weather predictions and saving life and property. 

From the vantage of the station, the LIS instrument will sample lightning over a wider geographical area than any previous sensor.

Future robotic spacecraft will need advanced autopilot systems to help them safely navigate and rendezvous with other objects, as they will be operating thousands of miles from Earth. 

The Raven (STP-H5 Raven) studies a real-time spacecraft navigation system that provides the eyes and intelligence to see a target and steer toward it safely. Research from Raven can be applied toward unmanned vehicles both on Earth and in space, including potential use for systems in NASA’s future human deep space exploration.

SAGE III will measure stratospheric ozone, aerosols, and other trace gases by locking onto the sun or moon and scanning a thin profile of Earth’s atmosphere.

These measurements will allow national and international leaders to make informed policy decisions regarding the protection and preservation of Earth’s ozone layer. Ozone in the atmosphere protects Earth’s inhabitants, including humans, plants and animals, from harmful radiation from the sun, which can cause long-term problems such as cataracts, cancer and reduced crop yield.

Tissue Regeneration-Bone Defect (Rodent Research-4) a U.S. National Laboratory investigation sponsored by the Center for the Advancement of Science in Space (CASIS) and the U.S. Army Medical Research and Materiel Command, studies what prevents other vertebrates such as rodents and humans from re-growing lost bone and tissue, and how microgravity conditions impact the process. 

Results will provide a new understanding of the biological reasons behind a human’s inability to grow a lost limb at the wound site, and could lead to new treatment options for the more than 30% of the patient.

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