On November 9, 1967, The Uncrewed Apollo 4 Test Flight Made A Great Ellipse Around Earth As A Test Of

Tumour Markers

Chemical biomarkers that can be elevated by the presence of one or more types of cancer,  produced directly by the tumour or by non-tumour cells as a response to the presence of a tumour. Really great tests as can use just blood/urine, but aren’t the most specific and false positives do occur.

Alpha-fetoprotein (AFP) 

Glycoprotein synthesised in yolk sac, the foetal liver, and gut - will be high in a foetus and during pregnancy. 

<10 ng/mL is normal for adults

>500 ng/mL could indicate liver tumour

Normally:

Produced primarily by the liver in a developing foetus 

Thought to be a foetal form of albumin

suppress lymphocyte activation and antibody production in adults (immune suppressant)

Binds bilirubin, fatty acids, hormones and metals

In cancer:

Detects hepatocarcinoma (liver cancer)

Risk factors: haemochromotosis, hep B, alcoholism - cell repair and growth from this damage leads to cancers

Present in non-pathogenic liver proliferation, including the growth and repair response to the above. This makes it hard to differentiate - AFP levels can be raised in patients with liver cancer risk factors due to the factors themselves, not a cancer. Not very diagnostic!! Used in combination with other tests/factors. Sensitivity and specificity ~75%

Other hepatocellular carcinoma markers:

γGT (γ-glutamyltransferase) - biliary damage

AFP mRNA (not always together with AFP! Might not be activated)

γGT mRNA elevated

Raised cytokines (IL-8, VEGF, TGF-B1) 

ALT and AST elevated - liver disease

Carcinoembryonic antigen (CEA)

a set of highly related glycoproteins involved in cell adhesion. Potentially associated with innate immune system.

Normally:

produced in gastrointestinal tissue during foetal development 

production stops before birth

present only at very low levels in the blood of healthy adults. 

Cancer:

Elevated in almost all patients with colorectal cancer

Can monitor recurrence of cancer (when compared to previous test results for that patient) with a sensitivity of 80% and specificity of 70%

levels may also be raised in gastric, pancreatic, lung, breast and medullary thyroid carcinomas

also some non-neoplastic (not cancer) conditions like ulcerative colitis, liver disease, pancreatitis,  COPD, Crohn’s disease, hypothyroidism - again, high risk groups for colorectal cancer - not a diagnostic test

Levels elevated in smokers.

Carbohydrate antigens (CA)

Including:

CA 19-9 - Pancreas

CA 15-3 Breast

CA 50 - Colorectal

CA 125 - ovarian

Levels rise only in disease states and particularly cancer, but will not rise in all patients.

Part 2 coming soon!

Types as Ya Boy Bill Nye quotes

ESFJ:

ESFP:

ESTJ:

ESTP:

ENFJ:

ENFP:

ENTJ:

ENTP:

ISFJ:

ISFP:

ISTJ:

ISTP:

INFJ:

INFP:

INTJ: 

INTP:

Sound metal, don't you think?

Engineers 3-D print high-strength aluminum, solve ages-old welding problem using nanoparticles

HRL Laboratories has made a breakthrough in metallurgy with the announcement that researchers at the famous facility have developed a technique for successfully 3D printing high-strength aluminum alloys—including types Al7075 and Al6061—that opens the door to additive manufacturing of engineering-relevant alloys. These alloys are very desirable for aircraft and automobile parts and have been among thousands that were not amenable to additive manufacturing—3D printing—a difficulty that has been solved by the HRL researchers. An added benefit is that their method can be applied to additional alloy families such as high-strength steels and nickel-based superalloys difficult to process currently in additive manufacturing.

“We’re using a 70-year-old nucleation theory to solve a 100-year-old problem with a 21st century machine,” said Hunter Martin, who co-led the team with Brennan Yahata. Both are engineers in the HRL’s Sensors and Materials Laboratory and PhD students at University of California, Santa Barbara studying with Professor Tresa Pollock, a co-author on the study. Their paper 3D printing of high-strength aluminum alloys was published in the September 21, 2017 issue of Nature.

Additive manufacturing of metals typically begins with alloy powders that are applied in thin layers and heated with a laser or other direct heat source to melt and solidify the layers. Normally, if high-strength unweldable aluminum alloys such as Al7075 or AL6061 are used, the resulting parts suffer severe hot cracking—a condition that renders a metal part able to be pulled apart like a flaky biscuit.

Read more.

Vacuum printer. Fill up the empty space.

Meet The First-Ever 3D Printer That Can Do Construction in The Vacuum of Space

This will change how we explore space.

One manufacturing company just made history by successfully using a special 3D printer in extreme, space-like conditions.

The team printed polymer alloy parts in a super-high vacuum, and hope their new tech will allow the design and manufacture of much more ambitious spacecraft and space-based telescopes.

“This is an important milestone, because it means that we can now adaptively and on demand manufacture things in space,” Andrew Rush, CEO of Made in Space, told Scientific American.

Continue Reading.

I need some C - H - O - CO late

My friend just sent me this so y'all have to suffer too

Breakthrough in blending metals—precise control of multimetallic one-nanometer cluster formation achieved

Researchers in Japan have found a way to create innovative materials by blending metals with precision control. Their approach, based on a concept called atom hybridization, opens up an unexplored area of chemistry that could lead to the development of advanced functional materials.

Multimetallic clusters—typically composed of three or more metals—are garnering attention as they exhibit properties that cannot be attained by single-metal materials. If a variety of metal elements are freely blended, it is expected that as-yet-unknown substances are discovered and highly-functional materials are developed. So far, no one had reported the multimetallic clusters blended with more than four metal elements so far because of unfavorable separation of different metals. One idea to overcome this difficulty is miniaturization of cluster sizes to one-nanometer scale, which forces the different metals to be blended in a small space. However, there was no way to realize this idea.

Read more.

Food for thought

We might won`t need a last supper yet

PINning down future problems

Study finds hackers could use brainwaves to steal passwords

Researchers at the University of Alabama at Birmingham suggest that brainwave-sensing headsets, also known as EEG or electroencephalograph headsets, need better security after a study reveals hackers could guess a user’s passwords by monitoring their brainwaves.

EEG headsets are advertised as allowing users to use only their brains to control robotic toys and video games specifically developed to be played with an EEG headset. There are only a handful on the market, and they range in price from $150 to $800.

Nitesh Saxena, Ph.D., associate professor in the UAB College of Arts and Sciences Department of Computer and Information Sciences, and Ph.D. student Ajaya Neupane and former master’s student Md Lutfor Rahman, found that a person who paused a video game and logged into a bank account while wearing an EEG headset was at risk for having their passwords or other sensitive data stolen by a malicious software program.

“These emerging devices open immense opportunities for everyday users,” Saxena said. “However, they could also raise significant security and privacy threats as companies work to develop even more advanced brain-computer interface technology.”

Saxena and his team used one EEG headset currently available to consumers online and one clinical-grade headset used for scientific research to demonstrate how easily a malicious software program could passively eavesdrop on a user’s brainwaves. While typing, a user’s inputs correspond with their visual processing, as well as hand, eye and head muscle movements. All these movements are captured by EEG headsets. The team asked 12 people to type a series of randomly generated PINs and passwords into a text box as if they were logging into an online account while wearing an EEG headset, in order for the software to train itself on the user’s typing and the corresponding brainwave.

“In a real-world attack, a hacker could facilitate the training step required for the malicious program to be most accurate, by requesting that the user enter a predefined set of numbers in order to restart the game after pausing it to take a break, similar to the way CAPTCHA is used to verify users when logging onto websites,” Saxena said.

The team found that, after a user entered 200 characters, algorithms within the malicious software program could make educated guesses about new characters the user entered by monitoring the EEG data recorded. The algorithm was able to shorten the odds of a hacker’s guessing a four-digit numerical PIN from one in 10,000 to one in 20 and increased the chance of guessing a six-letter password from about 500,000 to roughly one in 500.

EEG has been used in the medical field for more than half a century as a noninvasive method for recording electrical activity in the brain. Electrodes are placed on the surface of the scalp to detect brain waves. An EEG machine then amplifies the signals and records them in a wave pattern on graph paper or a computer. EEG can be combined with a brain-computer interface to allow a person to control external devices. This technology was once highly expensive and used mostly for scientific research, like the production of neuroprosthetic applications to help disabled patients control prosthetic limbs by thinking about the movements. However, it is now being marketed to consumers in the form of a wireless headset and is becoming popular in the gaming and entertainment industries.

“Given the growing popularity of EEG headsets and the variety of ways in which they could be used, it is inevitable that they will become part of our daily lives, including while using other devices,” Saxena said. “It is important to analyze the potential security and privacy risks associated with this emerging technology to raise users’ awareness of the risks and develop viable solutions to malicious attacks.”

One potential solution proposed by Saxena and his team is the insertion of noise anytime a user types a password or PIN while wearing an EEG headset.

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Hmm